SNSPD enabled SWIR confocal fluorescence microscope

Tim Rambo; Yifan Liu; Cheng-You Yao; Bo Li; Aniwat Juhong; Jeremy Doredla; Stephanie Boyd; Amy Conover; Aaron Miller; Zhen Qiu

doi:10.1117/12.2691678

13 March 2024 SNSPD enabled SWIR confocal fluorescence microscope

Tim Rambo, Yifan Liu, Cheng-You Yao, Bo Li, Aniwat Juhong, Jeremy Doredla, Stephanie Boyd, Amy Conover, Aaron Miller, Zhen Qiu

Author Affiliations +

Proceedings Volume PC12863, Quantum Effects and Measurement Techniques in Biology and Biophotonics; PC128630T (2024) https://doi.org/10.1117/12.2691678
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Confocal fluorescence microscopy is a common imaging technique for biomedical applications such as tumor characterization, precision resections, etc... However, the imaging process is limited by photo bleaching of samples and optical scattering limits imposed by wavelength limitations of traditionally used detection technologies. Here we show that by leveraging the high detection efficiency and large spectral range of superconducting nanowire single-photon detectors, it is possible to image deeper into tissue with a significant reduction in laser excitation power compared to the same technique using silicon photo-multipliers.

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Citation Download Citation

Tim Rambo, Yifan Liu, Cheng-You Yao, Bo Li, Aniwat Juhong, Jeremy Doredla, Stephanie Boyd, Amy Conover, Aaron Miller, and Zhen Qiu "SNSPD enabled SWIR confocal fluorescence microscope", Proc. SPIE PC12863, Quantum Effects and Measurement Techniques in Biology and Biophotonics, PC128630T (13 March 2024); https://doi.org/10.1117/12.2691678

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