A Role For Photodynamic Therapy In Autologous Bone Marrow Transplantation

Fritz Sieber

doi:10.1117/12.942703

19 February 1988 A Role For Photodynamic Therapy In Autologous Bone Marrow Transplantation

Fritz Sieber

Proceedings Volume 0847, New Directions in Photodynamic Therapy; (1988) https://doi.org/10.1117/12.942703
Event: Cambridge Symposium on Optics in Medicine and Visual Image Processing, 1987, San Diego, CA, United States

Abstract

Simultaneous exposure to the amphipathic fluorescent dye merocyanine 540 (MC 540) and light of a suitable wavelength rapidly kills leukemia, lymphoma, and neuroblastoma cells but spares normal pluripotent hematopoietic stem cells. Tests in several preclinical models and early results of a phase I clinical trial suggest that MC 540-mediated photosensitization may be useful for the extracorporeal purging of autologous remission bone marrow grafts.

Citation Download Citation

Fritz Sieber "A Role For Photodynamic Therapy In Autologous Bone Marrow Transplantation", Proc. SPIE 0847, New Directions in Photodynamic Therapy, (19 February 1988); https://doi.org/10.1117/12.942703

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