Simultaneous measurements of total hemoglobin concentration and blood oxygenation with laser diode-based optoacoustic system

Irene Y. Petrov; Donald S. Prough M.D.; Yuriy Petrov; S. Nan Henkel; Roger Seeton; Rinat O. Esenaliev

doi:10.1117/12.2256169

27 March 2017 Simultaneous measurements of total hemoglobin concentration and blood oxygenation with laser diode-based optoacoustic system

Irene Y. Petrov, Donald S. Prough M.D., Yuriy Petrov, S. Nan Henkel, Roger Seeton, Rinat O. Esenaliev

Author Affiliations +

Proceedings Volume 10064, Photons Plus Ultrasound: Imaging and Sensing 2017; 100640P (2017) https://doi.org/10.1117/12.2256169
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Noninvasive, accurate, continuous monitoring of multiple variables, including blood oxygenation, i.e. oxyhemoglobin saturation (SO₂) and total hemoglobin concentration (THb) in both high acuity and low acuity environments would greatly facilitate prompt diagnosis and treatment of physiologic derangements. However, most of the existing techniques for patient monitoring are invasive, while noninvasive techniques often fail to provide accurate measurements. We built a compact, multi-wavelength, nanosecond, fiber-coupled laser diode-based optoacoustic system for noninvasive, accurate monitoring of blood SO₂ and THb in veins and arteries. We tested the system by probing the radial artery of healthy volunteers. Using blood samples obtained by venipuncture, we also measured a reference THb for each volunteer. Moreover, the optoacoustic data were compared with that obtained from a commercially available noninvasive monitor for measurements of these variables. The optoacoustic system provided rapid, simultaneous, and continuous measurement of THb and SO₂ with high precision. The obtained results are promising and we plan to further test the system in clinical studies and at conditions simulating circulatory shock.

Citation Download Citation

Irene Y. Petrov, Donald S. Prough M.D., Yuriy Petrov, S. Nan Henkel, Roger Seeton, and Rinat O. Esenaliev "Simultaneous measurements of total hemoglobin concentration and blood oxygenation with laser diode-based optoacoustic system", Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100640P (27 March 2017); https://doi.org/10.1117/12.2256169

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available