Model calculation on the efficiency of PDT by pulsed laser application

Hans-Jochen Foth

doi:10.1117/12.2283886

29 August 2017 Model calculation on the efficiency of PDT by pulsed laser application

Hans-Jochen Foth

Proceedings Volume 10313, Opto-Canada: SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging; 103132I (2017) https://doi.org/10.1117/12.2283886
Event: Opto-Canada: SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging, 2002, Ottawa, Ontario, Canada

Abstract

Model Calculations The tissue was modelled by the so called Krogh's cylinders, i.e. blood parallel vessels in a specific distance supply the tissue with oxygen. Oxygen transfer in the tissue takes place due to diffusion only which needs an decrease of oxygen concentration with increasing distance to the vessel. A oxygen diffusion rate of D = 2 10-5 cm /s was used. The rate equations for the population density in the levels of the photosensitizer molecule and in the oxygen molecule were build up. All transition shown in Fig. 1 have been considered with the marked rate constants. The system of coupled differential equations were solved numerically on a personal computer which needed computing time up to 36 hours.

Citation Download Citation

Hans-Jochen Foth "Model calculation on the efficiency of PDT by pulsed laser application", Proc. SPIE 10313, Opto-Canada: SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging, 103132I (29 August 2017); https://doi.org/10.1117/12.2283886

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