Nano-structured optical fiber bundles for remote SPR detection: a first step toward in vivo biomolecular analysis

Karim Vindas; Elodie Engel; Patrick Garrigue; Thierry Livache; Stéphane Arbault; Neso Sojic; Loic Leroy

doi:10.1117/12.2262559

23 April 2017 Nano-structured optical fiber bundles for remote SPR detection: a first step toward in vivo biomolecular analysis

Karim Vindas, Elodie Engel, Patrick Garrigue, Thierry Livache, Stéphane Arbault, Neso Sojic, Loic Leroy

Author Affiliations +

Proceedings Volume 10323, 25th International Conference on Optical Fiber Sensors; 1032307 (2017) https://doi.org/10.1117/12.2262559
Event: 25th International Conference on Optical Fiber Sensors, 2017, Jeju, Korea, Republic of

Abstract

This work presents the proof of concept of the detection of global and surface optical index variations by surface plasmon resonance (SPR) thanks to optical fiber bundles. This work is the first necessary step for the future design of a lab-on-fiber tool dedicated to molecular analysis for endoscopic diagnosis. Our approach is based on nanostructured optical fiber bundles comprising several thousands of individual optical fibers. These nanostructures were coated by a thin gold layer in order to gain interesting optical properties such like SPR. The sensitivity and resolution of the bundle to global optical index changes were measured in retro-reflection. We performed numerical simulations in order to optimize the fiber tip geometry, gold coating thickness and finally enhance their analytical performances. We achieved a resolution of 10^-4 refractive index unit, which is fully compatible with the detection of biological interactions involving large proteins or bacteria. Finally, we proved that our sensor was sensitive to surface optical index variations and able to detect the adsorption of a thin self-assembled molecular layer.

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Karim Vindas, Elodie Engel, Patrick Garrigue, Thierry Livache, Stéphane Arbault, Neso Sojic, and Loic Leroy "Nano-structured optical fiber bundles for remote SPR detection: a first step toward in vivo biomolecular analysis", Proc. SPIE 10323, 25th International Conference on Optical Fiber Sensors, 1032307 (23 April 2017); https://doi.org/10.1117/12.2262559

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