Optimization of a multi-color adaptive optics scanning laser ophthalmoscope design with diffraction-limited illumination and collection for high-throughput imaging (Conference Presentation)

Francesco LaRocca; Sanam Mozaffari; Volker Jaedicke; Austin Roorda

doi:10.1117/12.2292090

14 March 2018 Optimization of a multi-color adaptive optics scanning laser ophthalmoscope design with diffraction-limited illumination and collection for high-throughput imaging (Conference Presentation)

Francesco LaRocca, Sanam Mozaffari, Volker Jaedicke, Austin Roorda

Author Affiliations +

Proceedings Volume 10474, Ophthalmic Technologies XXVIII; 104740F (2018) https://doi.org/10.1117/12.2292090
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Current-generation adaptive optics scanning laser ophthalmoscopes (AOSLO) are typically able to compensate for the optical aberrations of the human eye and achieve diffraction-limited illumination over a wide vergence range. However, to maximize the light collection efficiency of such a system, it is also necessary to have a collection path that is diffraction-limited for each imaging channel. Although it is trivial to achieve a high collection efficiency for a single channel AOSLO or a multi-channel AOSLO with minimal vergence differences between channels, for larger vergence differences, a careful consideration of the collection optics and their position and orientation within the collection path is needed. We present a methodology and system design for achieving diffraction-limited performance in both the illumination and collection paths of a multi-color AOSLO. The system consists of three imaging channels spanning different wavelength ranges (543 ± 11 nm, 680 ± 11 nm, and 840 ± 6 nm, respectively) and one near-infrared wavefront sensing channel (940 ± 5 nm). The maximum vergence difference between channels (measured at the exit pupil of the system) is ~1.2 diopters to compensate for the chromatic focal shift of the human eye. Preliminary imaging results from a healthy human adult volunteer demonstrate the system’s ability to resolve the foveal cone mosaic in all three imaging channels.

Conference Presentation

Citation Download Citation

Francesco LaRocca, Sanam Mozaffari, Volker Jaedicke, and Austin Roorda "Optimization of a multi-color adaptive optics scanning laser ophthalmoscope design with diffraction-limited illumination and collection for high-throughput imaging (Conference Presentation)", Proc. SPIE 10474, Ophthalmic Technologies XXVIII, 104740F (14 March 2018); https://doi.org/10.1117/12.2292090

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KEYWORDS

Multichannel imaging systems

Adaptive optics

Eye

Imaging systems

Scanning laser ophthalmoscopes

Scanning laser ophthalmoscopy

Ophthalmic optics

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