Bronchial based pulmonary acinus analysis in human lungs using a synchrotron radiation micro-CT

K. Saito; Y. Kobayashi; Y. Kawata; N. Niki; K. Umetani; T. Okamoto; H. Sakai; Y. Nakano; H. Itoh

doi:10.1117/12.2293428

12 March 2018 Bronchial based pulmonary acinus analysis in human lungs using a synchrotron radiation micro-CT

K. Saito, Y. Kobayashi, Y. Kawata, N. Niki, K. Umetani, T. Okamoto, H. Sakai, Y. Nakano, H. Itoh

Proceedings Volume 10578, Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging; 105781W (2018) https://doi.org/10.1117/12.2293428
Event: SPIE Medical Imaging, 2018, Houston, Texas, United States

Abstract

Quantitative analyses of three-dimensional (3D) micro structures in human lungs can provide detailed information to elucidate pulmonary disease progress. The observation of tissue specimens in two-dimensional (2D) slice of lungs has a limited understanding of the whole of 3D lung peripheral structures. A 3D analysis of the human pulmonary acinus is fundamental to understand lung structure. However, we cannot yet thoroughly understand the 3D lung microstructure because of technical limitations. The lung specimens used in this study were fixed, inflated and dried according to the Heitzman method. Each lung specimen was taken in the beam line BL20B2 at SPring8. The present findings may give further insight in the 3D lung microstructure.

Citation Download Citation

K. Saito, Y. Kobayashi, Y. Kawata, N. Niki, K. Umetani, T. Okamoto, H. Sakai, Y. Nakano, and H. Itoh "Bronchial based pulmonary acinus analysis in human lungs using a synchrotron radiation micro-CT", Proc. SPIE 10578, Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging, 105781W (12 March 2018); https://doi.org/10.1117/12.2293428

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