Perfusion flow phantoms with randomly oriented microchannels

Mark K. George; Jaime E. Tierney; Adam C. Luchies; Kathryn A. Ozgun; Shannon Faley; Leon M. Bellan; Brett C. Byram

doi:10.1117/12.2296803

6 March 2018 Perfusion flow phantoms with randomly oriented microchannels

Mark K. George, Jaime E. Tierney, Adam C. Luchies, Kathryn A. Ozgun, Shannon Faley, Leon M. Bellan, Brett C. Byram

Proceedings Volume 10580, Medical Imaging 2018: Ultrasonic Imaging and Tomography; 1058006 (2018) https://doi.org/10.1117/12.2296803
Event: SPIE Medical Imaging, 2018, Houston, Texas, United States

Abstract

Interest in ultrasound perfusion imaging has grown with the development of more sensitive algorithms to detect slow blood flow. Unfortunately, there are not many phantoms that can be used to evaluate these techniques. Some have used small linear tubes, while others have adapted dialysis cartridges. Here we propose a technique using conventional gelatin cast around a sacrificial polymer network. Specifically, we form a gelatin phantom, doped with graphite scatterers to mimic the diffuse scattering in soft tissue, around a polymer resin. The resin structure can be dissolved leaving behind a network of small randomly oriented channels that are connected to a large channel which is connected to a pump to perfuse blood mimicking fluid through the phantom. The phantoms were qualitatively demonstrated to show perfusion through visual confirmation and the speckle SNR, and speed of sound were calculated.

Citation Download Citation

Mark K. George, Jaime E. Tierney, Adam C. Luchies, Kathryn A. Ozgun, Shannon Faley, Leon M. Bellan, and Brett C. Byram "Perfusion flow phantoms with randomly oriented microchannels", Proc. SPIE 10580, Medical Imaging 2018: Ultrasonic Imaging and Tomography, 1058006 (6 March 2018); https://doi.org/10.1117/12.2296803

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KEYWORDS

Blood

Speckle

Polymers

Tissues

Demodulation

Microfluidics

Ultrasonography

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