The PET/X dedicated breast-PET scanner for optimizing cancer therapy

Lawrence R. MacDonald; William C. J. Hunter; Chengeng Zeng; Larry A. Pierce II; Sergei Dolinski; Donald DeWitt; Robert S. Miyaoka; Paul E. Kinahan

doi:10.1117/12.2318419

6 July 2018 The PET/X dedicated breast-PET scanner for optimizing cancer therapy

Lawrence R. MacDonald, William C. J. Hunter, Chengeng Zeng, Larry A. Pierce II, Sergei Dolinski, Donald DeWitt, Robert S. Miyaoka, Paul E. Kinahan

Author Affiliations +

Proceedings Volume 10718, 14th International Workshop on Breast Imaging (IWBI 2018); 107180M (2018) https://doi.org/10.1117/12.2318419
Event: The Fourteenth International Workshop on Breast Imaging, 2018, Atlanta, Georgia, United States

Abstract

We are currently building the PET/X scanner, which is a breast positron emission tomography (PET) scanner combined with a standard X-ray mammography system. The role for the PET/X scanner is to precisely measure changes in radiotracer uptake after an initial test dose of adjuvant or neoadjuvant therapy. The system performance target is that a measured 20% change in tracer uptake in 5 mm diameter lesions with standardized uptake value (SUV) of 5 g/ml should correspond to at least 95% specificity (<5% false positive rate for detecting a true change in uptake). Simulations indicate that this performance can be achieved with a 3-minute scan of a 370-MBq (10-mCi) injection of 18F-FDG or other radiotracers.

The PET scanner consists of 4 planar detectors, forming a rectangular system with complete azimuthal angular sampling (around the z-axis). The panels are formed of detector blocks each using a 20x20 array of LYSO scintillation crystals (2x2x10mm³) coupled to a 12x12 array of 3x3 mm²pixel silicon photomultipliers (SiPMs). The overall system size is 24cm wide (6 blocks) by 16cm deep (4 blocks axially) by 4-to-12cm adjustable height.

The PET system mounts on a mammography scanner by swapping out the standard 'bucky' unit. Patients are scanned in both mammography and PET modes without movement to allow co-registration of the two image sets. Here, we review the system design, construction, and initial performance measures.

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Lawrence R. MacDonald, William C. J. Hunter, Chengeng Zeng, Larry A. Pierce II, Sergei Dolinski, Donald DeWitt, Robert S. Miyaoka, and Paul E. Kinahan "The PET/X dedicated breast-PET scanner for optimizing cancer therapy", Proc. SPIE 10718, 14th International Workshop on Breast Imaging (IWBI 2018), 107180M (6 July 2018); https://doi.org/10.1117/12.2318419

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