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4 March 2019 Combining ionising radiation with nanoconstructs: towards new options in cancer therapy (Conference Presentation)
Ewa M. Goldys, Sandhya Clement, Wei Deng
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Proceedings Volume 10862, Molecular-Guided Surgery: Molecules, Devices, and Applications V; 1086215 (2019) https://doi.org/10.1117/12.2511905
Event: SPIE BiOS, 2019, San Francisco, California, United States
Abstract
Chemo- and/or radiotherapy remain treatment standards for cancer. Clinical challenges including poor tumour specificity and cause dose-dependent side effects. The proposed new treatment modality combining radiation and radiation-triggered nanoconstructs can selectively target and efficiently destroy deep-seated tumours. To achieve this, we combined existing clinical techniques used in cancer treatment–X-ray radiation and other treatment modalities including chemotherapy and photodynamic therapy by using various nanoparticles which we successfully developed. They included scintillator nanoparticles (CeF3), Au nanoparticles, Poly Lactic-co-Glycolic Acid (PLGA) polymer and liposome nanoparticles. A photosensitive molecule, verteporfin was either conjugated (in the case of CeF3) or loaded inside the nanoparticles (in the case of PLGA polymer and liposomes). Their unique combination enables effective ablation of cancer cells in vitro and control of tumour growth in vivo at a low X-ray dose, which was conclusively demonstrated by our recent work.
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Ewa M. Goldys, Sandhya Clement, and Wei Deng "Combining ionising radiation with nanoconstructs: towards new options in cancer therapy (Conference Presentation)", Proc. SPIE 10862, Molecular-Guided Surgery: Molecules, Devices, and Applications V, 1086215 (4 March 2019); https://doi.org/10.1117/12.2511905
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KEYWORDS
Cancer
Nanoparticles
Ionizing radiation
Oncology
Polymers
Gold
Molecules
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