Hyperspectral, hybrid continuous wave and frequency domain diffuse optical tomography in a handheld reflectance geometry for breast cancer diagnostics

Sandhya Vasudevan; Farnoush Forghani; Chris Campbell; Vincent Kitsmiller; Thomas D. O'Sullivan

doi:10.1117/12.2509111

1 March 2019 Hyperspectral, hybrid continuous wave and frequency domain diffuse optical tomography in a handheld reflectance geometry for breast cancer diagnostics

Sandhya Vasudevan, Farnoush Forghani, Chris Campbell, Vincent Kitsmiller, Thomas D. O'Sullivan

Author Affiliations +

Proceedings Volume 10874, Optical Tomography and Spectroscopy of Tissue XIII; 108740J (2019) https://doi.org/10.1117/12.2509111
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Reflectance-based, handheld diffuse optical tomography (DOT) uses multi-spectral frequency-domain (FD) and/or continuous-wave (CW) discrete wavelength sources. During DOT reconstruction, spectral constraints are commonly applied assuming a limited number of chromophores in the tissue in order to more accurately recover chromophore concentrations and scattering parameters. However, there are cases where spectral recovery cannot be applied, such as for the quantification of unknown tissue absorbers, where the chromophore extinction spectra are not known a priori. Therefore, we have worked toward a hyperspectral, hybrid FD and CW-DOT approach that can accurately recover tissue absorption and scattering spectra without needing a spectral constraint. Our approach increases the number of recoverable chromophores continuously across a 650 - 1050 nm spectrum. We have implemented and evaluated this technique in a prototype handheld probe for reflectance-mode breast imaging. Currently, no handheld portable DOT probe has this broadband hyperspectral capability. We simulated the accuracy of optical property recovery, showing that hybrid DOT successfully recovers the absorption spectra with average of 10% error across 650 − 1000 nm spectrum. We have also validated this technique by successfully imaging an inhomogeneous physical phantom with optical properties mimicking breast tissue. The methodology for the probe design along with the results of simulations and phantom studies are presented.

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Sandhya Vasudevan, Farnoush Forghani, Chris Campbell, Vincent Kitsmiller, and Thomas D. O'Sullivan "Hyperspectral, hybrid continuous wave and frequency domain diffuse optical tomography in a handheld reflectance geometry for breast cancer diagnostics", Proc. SPIE 10874, Optical Tomography and Spectroscopy of Tissue XIII, 108740J (1 March 2019); https://doi.org/10.1117/12.2509111

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KEYWORDS

Tumors

Absorption

Tissue optics

Optical properties

Scattering

Chromophores

Diffuse optical tomography

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