CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 10885 > Article
Presentation
13 March 2019 Optical waveguides for on-chip fluorescence measurements (Conference Presentation)
Pao T. Lin, Gerard Cote, Kristen Maitland, Tiening Jin, Junchao Zhou, Paul Gordon, Cyril Soliman
Author Affiliations +
Proceedings Volume 10885, Optical Diagnostics and Sensing XIX: Toward Point-of-Care Diagnostics; 108850K (2019) https://doi.org/10.1117/12.2508228
Event: SPIE BiOS, 2019, San Francisco, California, United States
Abstract
Optical waveguides using a visible transparent nitride were developed to perform fluorescence measurement on a chip. Through finite difference time domain (FDTD) design, the exciting green light was guided by the micron-scale ridge waveguide, while its evanescent wave was expanded outside the waveguide surface and capable to efficiently excite the fluorescent molecules that were approaching the waveguide facets. Since the waveguide was centimeters long, it has a longer fluorescence excitation path comparing to traditional samples prepared for microscopy measurements. As result, the waveguide device can excite stronger fluorescent signals. In addition, the nitride waveguide was prepared by the complementary metal–oxide–semiconductor (CMOS) process thus enabling high volume manufacturing and reducing the cost of the device fabrication. The AlN waveguide was then integrated with a microfluidic devices to experimentally demonstrate real-time fluorescence detection. Solution samples with different dye concentrations were sequentially injected into the microfluidic chamber. By recording the emission signals, we showed that the fluorescent signals were consistently amplified as the dye concentrations increased. In addition, real-time fluorescence detection with a response time less than seconds was achieved. The developed waveguide based fluorescence measurement provides a new miniaturized platform for low cost and highly accurate point-of-care application.
Conference Presentation
© (2019) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Pao T. Lin, Gerard Cote, Kristen Maitland, Tiening Jin, Junchao Zhou, Paul Gordon, and Cyril Soliman "Optical waveguides for on-chip fluorescence measurements (Conference Presentation)", Proc. SPIE 10885, Optical Diagnostics and Sensing XIX: Toward Point-of-Care Diagnostics, 108850K (13 March 2019); https://doi.org/10.1117/12.2508228
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Waveguides
Luminescence
Finite-difference time-domain method
Fluorescence spectroscopy
Microfluidics
Aluminum nitride
High volume manufacturing
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top