Long-range surface plasmon waveguide biosensors for disease detection

Oleksiy Krupin; Wei Ru Wong; Pierre Berini

doi:10.1117/12.2513773

7 March 2019 Long-range surface plasmon waveguide biosensors for disease detection

Oleksiy Krupin, Wei Ru Wong, Pierre Berini

Proceedings Volume 10895, Frontiers in Biological Detection: From Nanosensors to Systems XI; 108950T (2019) https://doi.org/10.1117/12.2513773
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

We review long-range surface plasmon-polariton waveguide biosensors and their application to disease detection in complex fluids. The biosensors are constructed from metal stripe waveguides cladded in Cytop with etched microfluidic channels to expose the stripe surface to the sensing fluid. Application of waveguide biosensors to the detection of leukemia in patient blood serum and dengue infection in patient blood plasma is reviewed. In addition, a novel bioassay for HIV detection in complex fluids is proposed and preliminary results are demonstrated. The biosensors are compact and mass manufacturable using semiconductor fabrication tools and processes.

Conference Presentation

Citation Download Citation

Oleksiy Krupin, Wei Ru Wong, and Pierre Berini "Long-range surface plasmon waveguide biosensors for disease detection", Proc. SPIE 10895, Frontiers in Biological Detection: From Nanosensors to Systems XI, 108950T (7 March 2019); https://doi.org/10.1117/12.2513773

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