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Main clinical PDT application is still on non-melanoma skin cancer, using topical photosensitization with ALA-based compounds. For systemic oncological PDT, head and neck cancers are the main indication. In Latin America, several researchers have been working to develop protocols and light sources to improve the treatment success and to allow a lower cost procedure, relevant factors especially when considering low setting facilities and large populations. In this talk, we will present examples of instrumentation development and clinical protocols. For topical PDT, different strategies have been proposed to enhance the transdermal delivery of the ALA, considering its depth penetration and the homogeneity of PpIX production. ALA delivery methods using a dermography device and soluble microneedles patch have been under clinical investigation. We will also present the proposal of the Single session MAL-PDT for basal cell carcinoma, where both PDT applications are performed at the same day. The conventional protocol of 2 PDT sessions one week apart is an important limitation for patients that have to travel long distances to receive medical care. Another relevant medical problem that PDT has also been showing promising results is the cervical intraneoplasia. A Brazilian-Mexican device and different fiber-based protocols have been tested in a clinical study for CIN 1-3. The results will be presented, also discussing the strategies for improving irradiation of the lesions.
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