High resolution imaging of tumor pO2 with Cherenkov-excited luminescence scanned imaging (Conference Presentation)

Brian W. Pogue; Ethan LaRochelle; Xu Cao; Jason Gunn; Jennifer A. Shell; Cuiping Yao; Sergei A. Vinogradov

doi:10.1117/12.2525602

14 August 2019 High resolution imaging of tumor pO2 with Cherenkov-excited luminescence scanned imaging (Conference Presentation)

Brian W. Pogue, Ethan LaRochelle, Xu Cao, Jason Gunn, Jennifer A. Shell, Cuiping Yao, Sergei A. Vinogradov

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Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 110705E (2019) https://doi.org/10.1117/12.2525602
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States

Abstract

Cherenkov excitation of molecular probes in tissue can be used for photodynamic effect or diagnostic luminescence imaging. Excitation of dendritic platinum-based metalloporphyrn molecule complexes as an oxygen sensor (PtG4) has been shown to allow oxygen measurement in vivo with spatial resolution defined by the exciting x-ray beam. By sweeping the beamlet shapes and geometries, and detecting the emitted luminscence lifetime, a highly accurate pO2 distribution can be reconstructed of the tissue volume. This has been shown in tumors as well as in normal tissues, and now for implanted microtubes. Additional imaging of luminescent agents based upon Cherenkov or direct radio-excitation could be used for molecular sensing. The combination of depth, concentration, and radiation dose have been analyzed for the tradeoffs in signal to noise, and the signal to background optimization has been completed. The use of this approach can be applied to any clinical radiation therapy linac.

Conference Presentation

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Brian W. Pogue, Ethan LaRochelle, Xu Cao, Jason Gunn, Jennifer A. Shell, Cuiping Yao, and Sergei A. Vinogradov "High resolution imaging of tumor pO2 with Cherenkov-excited luminescence scanned imaging (Conference Presentation)", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110705E (14 August 2019); https://doi.org/10.1117/12.2525602

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KEYWORDS

Luminescence

Tumors

Image resolution

Oxygen

Tissues

Diagnostics

In vivo imaging

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