The influence of hypericin-mediated photodynamic therapy on secretion of selected interleukins by colon cancer cells in vitro

Aleksandra Kawczyk-Krupka; Marta Kaleta-Richter; Anna Miedzybrodzka; Wojciech Latos; Aleksander Sieron; Grzegorz Cieslar

doi:10.1117/12.2525516

7 August 2019 The influence of hypericin-mediated photodynamic therapy on secretion of selected interleukins by colon cancer cells in vitro

Aleksandra Kawczyk-Krupka, Marta Kaleta-Richter, Anna Miedzybrodzka, Wojciech Latos, Aleksander Sieron, Grzegorz Cieslar

Author Affiliations +

Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 11070A2 (2019) https://doi.org/10.1117/12.2525516
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States

Abstract

Aim of the study was to determine the immune effect of PDT with hypericin (HY-PDT) used in sublethal doses on the secretion of Interleukin 8 and 10 by experimental models of residual colon cancer cells in vitro. Results HY-PDT amplified the secretion of IL-8 by SW620 cell line, but the decrease of IL-8 secreted by the SW480 cell line. The increase in secretion of IL-10 was noticed in the SW480 cell line, but the changes of secretion IL-10 by SW 620 was not noted. SW480 cell line without PDT secreted higher levels of IL-8 and IL-10 than SW620 cells. Based on these research findings it could be told, that PDT both eliminates and control primary tumors using cytotoxic effect while HY-PDT at lower doses can modulate function of tumor microenvironment by releasing interleukins depended on metastatic activity of tumor cells.

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Aleksandra Kawczyk-Krupka, Marta Kaleta-Richter, Anna Miedzybrodzka, Wojciech Latos, Aleksander Sieron, and Grzegorz Cieslar "The influence of hypericin-mediated photodynamic therapy on secretion of selected interleukins by colon cancer cells in vitro", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 11070A2 (7 August 2019); https://doi.org/10.1117/12.2525516

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