Comparative analysis of single- and dual-wavelength low dose photodynamic therapy regimens

Daria A. Kurakina; Aleksandr V. Khilov; Maria A. Shakhova; Natalia Yu. Orlinskaya; Mikhail Yu. Kirillin

doi:10.1117/12.2527108

22 July 2019 Comparative analysis of single- and dual-wavelength low dose photodynamic therapy regimens

Daria A. Kurakina, Aleksandr V. Khilov, Maria A. Shakhova, Natalia Yu. Orlinskaya, Mikhail Yu. Kirillin

Proceedings Volume 11079, Medical Laser Applications and Laser-Tissue Interactions IX; 110791K (2019) https://doi.org/10.1117/12.2527108
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

Dual-wavelength photodynamic therapy is a photodynamic therapy (PDT) modality combining therapeutic effects of irradiation at two wavelengths of different region of visible range. In this paper we report on comparative analysis of single- and dual-wavelength PDT regimes based on multimodal optical monitoring of tissue response with histologic verification. Morphological and functional tissue responses to PDT procedure with chlorin-based photosensitizer (PS) were studied at the normal skin of a rabbit ear inner surface. Multimodal optical monitoring was performed by OCT and dual-wavelength fluorescence technique. The studied doses vary from 50 to 150 J/cm² delivered separately at 405 or 660 nm, or at both wavelengths together in the equal dose.

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Daria A. Kurakina, Aleksandr V. Khilov, Maria A. Shakhova, Natalia Yu. Orlinskaya, and Mikhail Yu. Kirillin "Comparative analysis of single- and dual-wavelength low dose photodynamic therapy regimens", Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX, 110791K (22 July 2019); https://doi.org/10.1117/12.2527108

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KEYWORDS

Photodynamic therapy

Optical coherence tomography

Tissue optics

Tissues

Absorption

Luminescence

Algorithm development

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