Preliminary study of sonodynamic effects of a novel water soluble chlorin

Jiang Jie; Jian Zou; Rui Ding; Zhen Han; Weijun Li; Zheng Huang

doi:10.1117/12.2537785

20 November 2019 Preliminary study of sonodynamic effects of a novel water soluble chlorin

Jiang Jie, Jian Zou, Rui Ding, Zhen Han, Weijun Li, Zheng Huang

Proceedings Volume 11190, Optics in Health Care and Biomedical Optics IX; 1119016 (2019) https://doi.org/10.1117/12.2537785
Event: SPIE/COS Photonics Asia, 2019, Hangzhou, China

Abstract

Early studies suggest that some PDT photosensitizers can be used as sonosensitizer for sonodynamic therapy (SDT). In this study, sonodynamic effects of a novel water soluble chlorin YLG-1 were evaluated. SDT of YLG-1 solution was carried out using an ultrasound transducer of 450 KHz at 2.0 W/cm² for 0 – 600 s. Comparison of spectroscopic profiles of YLG-1 before and after SDT demonstrated that sonification could cause the reduction of YLG-1 absorbance and fluorescence emission but did not cause obvious change of the Raman spectrum. No significant by-products were identified from spectroscopic study. Nevertheless, this study demonstrated that the sonification mediated sensitizer fluorescence bleaching effect could be partially blocked by the addition of NaN3, which suggests a possible involvement of singlet oxygen in the process of sonification of YLG-1 compound.

Citation Download Citation

Jiang Jie, Jian Zou, Rui Ding, Zhen Han, Weijun Li, and Zheng Huang "Preliminary study of sonodynamic effects of a novel water soluble chlorin", Proc. SPIE 11190, Optics in Health Care and Biomedical Optics IX, 1119016 (20 November 2019); https://doi.org/10.1117/12.2537785

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