Multispectral nanoparticle tracking analysis for the real-time characterization of amyloid-β self assembly in vitro (Conference Presentation)

Colman Moore; Ryan Wing; Jesse V. Jokerst

doi:10.1117/12.2546360

9 March 2020 Multispectral nanoparticle tracking analysis for the real-time characterization of amyloid-β self assembly in vitro (Conference Presentation)

Colman Moore, Ryan Wing, Jesse V. Jokerst

Author Affiliations +

Proceedings Volume 11216, Multiscale Imaging and Spectroscopy; 1121603 (2020) https://doi.org/10.1117/12.2546360
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

There has been little headway against Alzheimer’s disease despite decades of research into causes, conditions, and cures. Much of this effort has focused on the amyloid beta protein; however, it remains unclear whether it plays a causative or correlative role. Amyloid beta is notoriously difficult to study, and many of the current tools to monitor oligomerization and fibril formation are inadequate and are incapable of measuring the subtle details of plaque formation and deformation. Our preliminary data suggests that multispectral nanoparticle analysis can monitor the sigmoidal self-assembly (R2 = 0.94) of physiologically relevant populations of amyloid beta aggregates in real-time with single fibril resolution.

Conference Presentation

Citation Download Citation

Colman Moore, Ryan Wing, and Jesse V. Jokerst "Multispectral nanoparticle tracking analysis for the real-time characterization of amyloid-β self assembly in vitro (Conference Presentation)", Proc. SPIE 11216, Multiscale Imaging and Spectroscopy, 1121603 (9 March 2020); https://doi.org/10.1117/12.2546360

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