Using fluorescence laminar optical tomography to measure the distribution photodynamic drug in the brain to optimize dosage and treatment time (Conference Presentation)

Brandon Gaitan; Collin T. Inglut; Yu Chen; Huang-Chiao Huang

doi:10.1117/12.2550498

20 April 2020 Using fluorescence laminar optical tomography to measure the distribution photodynamic drug in the brain to optimize dosage and treatment time (Conference Presentation)

Brandon Gaitan, Collin T. Inglut, Yu Chen, Huang-Chiao Huang

Author Affiliations +

Proceedings Volume 11219, Visualizing and Quantifying Drug Distribution in Tissue IV; 112190J (2020) https://doi.org/10.1117/12.2550498
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Glioblastoma has a high rate of recurrence due to treatment methods often failing to penetrate the blood brain barrier. To overcome this limitation, photodynamic priming (PDP) can be used to increase tissue permeability. In this study we investigate the feasibility of using fluorescence laminar optical tomography (FLOT) to provide quantitative distribution information on photodynamic drug in the brain to optimize the timing of PDP. The project will result in a non-invasive way to quantify the concentration of photodynamic drug in the brain. This would allow for optimized treatment times, leading to improved patient outcomes.

Conference Presentation

Citation Download Citation

Brandon Gaitan, Collin T. Inglut, Yu Chen, and Huang-Chiao Huang "Using fluorescence laminar optical tomography to measure the distribution photodynamic drug in the brain to optimize dosage and treatment time (Conference Presentation)", Proc. SPIE 11219, Visualizing and Quantifying Drug Distribution in Tissue IV, 112190J (20 April 2020); https://doi.org/10.1117/12.2550498

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