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The cellular microenvironment in disease models is increasingly being recognized as a key contributing factor in disease onset and progression. Particularly in cancer, key features of the cellular microenvironment such as metabolic fluxes and organization of the collagen rich extracellular matrix (ECM) have been demonstrated to be candidate image based biomarkers for cancer invasion and progression. However despite the great promise of these microenvironment image features, their application to classic wound models has been limited for several reasons including a lack of appropriate methods and instrumentation for clinical wound application. We will overview our collaborative work to quantitate metabolism and ECM organization in a range of wound models all using a combination of both intrinsic and extrinsic multiparametric optical signals. These signals includes polarization, fluorescence intensity, spectra and lifetime. We will discuss technical approaches and advances for each and early efforts to extend these to Fluorescence image-guided surgery (FIGS) application.
Kevin W. Eliceiri
"Imaging the cellular microenvironment in surgical wounds (Conference Presentation)", Proc. SPIE 11222, Molecular-Guided Surgery: Molecules, Devices, and Applications VI, 112220B (10 March 2020); https://doi.org/10.1117/12.2555596
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Kevin W. Eliceiri, "Imaging the cellular microenvironment in surgical wounds (Conference Presentation)," Proc. SPIE 11222, Molecular-Guided Surgery: Molecules, Devices, and Applications VI, 112220B (10 March 2020); https://doi.org/10.1117/12.2555596