In vivo imaging of shock wave-induced nitric oxide generation in the rat cortex (Conference Presentation)

Masaki Inaba; Satoko Kawauchi; Takeshi Adachi; Shunichi Sato; Izumi Nishidate

doi:10.1117/12.2545452

9 March 2020 In vivo imaging of shock wave-induced nitric oxide generation in the rat cortex (Conference Presentation)

Masaki Inaba, Satoko Kawauchi, Takeshi Adachi, Shunichi Sato, Izumi Nishidate

Proceedings Volume 11225, Clinical and Translational Neurophotonics 2020; 1122504 (2020) https://doi.org/10.1117/12.2545452
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We hypothesized that generation of nitric oxide (NO) was associated with persistent hemodynamic abnormalities observed in the rat cortex exposed to a shock wave. To examine this speculation, we performed in vivo imaging of NO in the rat cortex exposed to a laser-induced shock wave (LISW). An NO sensitive fluoroprobe (DAF-2 DA) was applied to the cortical surface, and NO-originating fluorescence was observed under the stereoscopic fluorescence microscope. We observed that the fluorescence intensity in perivascular spaces as well as in parenchyma was drastically increased after LISW application. Intense fluorescence spots in the parenchyma probably indicate NO generation from neurons.

Conference Presentation

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Masaki Inaba, Satoko Kawauchi, Takeshi Adachi, Shunichi Sato, and Izumi Nishidate "In vivo imaging of shock wave-induced nitric oxide generation in the rat cortex (Conference Presentation)", Proc. SPIE 11225, Clinical and Translational Neurophotonics 2020, 1122504 (9 March 2020); https://doi.org/10.1117/12.2545452

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KEYWORDS

In vivo imaging

NOx

Luminescence

Brain

Blood vessels

Bone

Cranial windows

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