Phase dual-slopes for enhanced depth sensitivity in diffuse optical imaging (Conference Presentation)

Sergio Fantini; Angelo Sassaroli; Giles Blaney; Thao Pham; Cristianne Fernandez

doi:10.1117/12.2545188

9 March 2020 Phase dual-slopes for enhanced depth sensitivity in diffuse optical imaging (Conference Presentation)

Sergio Fantini, Angelo Sassaroli, Giles Blaney, Thao Pham, Cristianne Fernandez

Proceedings Volume 11226, Neural Imaging and Sensing 2020; 1122607 (2020) https://doi.org/10.1117/12.2545188
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We introduce a novel method to enhance the sensitivity of near-infrared spectroscopy (NIRS) to deep tissue (i.e. brain cortex, skeletal muscle, etc.) in non-invasive diffuse optical measurements. Our method relies on the collection of the phase of photon-density waves, launched by intensity-modulated light in frequency-domain NIRS, from two paired sets of multi-distance data. The two sets of data are combined into a phase dual-slope, which features a stronger sensitivity to deeper vs. superficial tissue. For typical conditions of functional NIRS, the maximum sensitivity of phase dual-slopes is at a depth of ~11 mm, which approaches the depth of cortical tissue.

Conference Presentation

Citation Download Citation

Sergio Fantini, Angelo Sassaroli, Giles Blaney, Thao Pham, and Cristianne Fernandez "Phase dual-slopes for enhanced depth sensitivity in diffuse optical imaging (Conference Presentation)", Proc. SPIE 11226, Neural Imaging and Sensing 2020, 1122607 (9 March 2020); https://doi.org/10.1117/12.2545188

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