Integrated photonics chip for neural activity investigation

Corinna Kaspar; Julia Lehrich; Aleksander Ivanenko; Jürgen Klingauf; Wolfram Pernice

doi:10.1117/12.2546183

19 February 2020 Integrated photonics chip for neural activity investigation

Corinna Kaspar, Julia Lehrich, Aleksander Ivanenko, Jürgen Klingauf, Wolfram Pernice

Proceedings Volume 11227, Optogenetics and Optical Manipulation 2020; 1122703 (2020) https://doi.org/10.1117/12.2546183
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Understanding the central nervous system and the human brain in particular represents one of the most challenging endeavors in current science. This interest is not only driven by the need to find new methods for curing neural disorders. Increasing efforts are dedicated to the development of hardware mimics of the nervous system in the form of artificial neural networks for computational purposes, which also reflects substantial interest in a deeper understanding of the brain’s functionality. Here, we present a nanophotonic approach to enable a precise investigation of neural activity at the level of a single synapse. Key component is an integrated photonic chip, which serves as a platform for neural growth. Our simulations show, that an optogenetically modified nerve cell in close vicinity to a photonic waveguide can be efficiently stimulated by the waveguide’s evanescent field, even with a low optical input power in the order of microwatts. These results pave the way for designing a versatile analysis tool to investigate both the behavior of individual neurons and their synergistic function in a neural network at the same time.

Citation Download Citation

Corinna Kaspar, Julia Lehrich, Aleksander Ivanenko, Jürgen Klingauf, and Wolfram Pernice "Integrated photonics chip for neural activity investigation", Proc. SPIE 11227, Optogenetics and Optical Manipulation 2020, 1122703 (19 February 2020); https://doi.org/10.1117/12.2546183

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Waveguides

Neurons

Wave propagation

Action potentials

Integrated photonics

Dendrites

Silicon

Show All Keywords

Keywords/Phrases

Search In:

Publication Years