Classifying diffuse reflectance spectroscopy measurements of locations with mixed tissue types and DCIS (Conference Presentation)

Lisanne L. de Boer; Esther Kho; Marie-Jeanne T. F. D. Vrancken Peeters; Frederieke van Duijnhoven; Koen K. Van de Vijver; Joyce Sanders; Benno H. W. Hendriks; Henricus J. C. M. Sterenborg; Theo J. M. Ruers

doi:10.1117/12.2545569

9 March 2020 Classifying diffuse reflectance spectroscopy measurements of locations with mixed tissue types and DCIS (Conference Presentation)

Lisanne L. de Boer, Esther Kho, Marie-Jeanne T. F. D. Vrancken Peeters, Frederieke van Duijnhoven, Koen K. Van de Vijver, Joyce Sanders, Benno H. W. Hendriks, Henricus J. C. M. Sterenborg, Theo J. M. Ruers

Author Affiliations +

Proceedings Volume 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis; 112340T (2020) https://doi.org/10.1117/12.2545569
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Diffuse Reflectance Spectroscopy (DRS) measurements can discriminate pure fat tissue from pure invasive carcinoma. Here we investigate 1) the difference between DRS measurements of invasive carcinoma and ductal carcinoma in situ (DCIS), and 2) the classification accuracy of DRS measurements of a mixture of tissue types. DRS measurements (850–1600nm) were acquired from 107 slices (n = 1493 locations) of breast specimens. There were no significant differences between the DRS spectra of invasive carcinoma or DCIS. All locations with >75% malignant tissue were correctly classified, including DCIS locations. With a decreasing percentage of malignant tissue, the classification accuracy decreased.

Conference Presentation

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Lisanne L. de Boer, Esther Kho, Marie-Jeanne T. F. D. Vrancken Peeters, Frederieke van Duijnhoven, Koen K. Van de Vijver, Joyce Sanders, Benno H. W. Hendriks, Henricus J. C. M. Sterenborg, and Theo J. M. Ruers "Classifying diffuse reflectance spectroscopy measurements of locations with mixed tissue types and DCIS (Conference Presentation)", Proc. SPIE 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 112340T (9 March 2020); https://doi.org/10.1117/12.2545569

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KEYWORDS

Tissues

Diffuse reflectance spectroscopy

Tissue optics

Tumor growth modeling

Performance modeling

Surgery

Breast

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