Intra-operative assessment of tumor resection margins by Raman spectroscopy to guide oral cancer surgery (Conference Presentation)

Gerwin J. Puppels; Elisa M. L. Barroso; Yassine Aaboubout; Maria Rosa Nunes Soares; Viacheslav G. Artyushenko; Alexey Bocharnikov; Iskander Usenov; Tom C. Bakker-Schut; Robert J. Baatenburg de Jong; Eppo Wolvius; Ivo ten Hove; Hetty Mast M.D.; Jose A. U. Hardillo; Aniel Sewnaik; Cees Meeuwis M.D.; Florence van Lanschot; Dominiek Monserez; Stijn Keereweer; Martin van der Wolf; Elena Sokolova; Senada Koljenovic

doi:10.1117/12.2544394

9 March 2020 Intra-operative assessment of tumor resection margins by Raman spectroscopy to guide oral cancer surgery (Conference Presentation)

Gerwin J. Puppels, Elisa M. L. Barroso, Yassine Aaboubout, Maria Rosa Nunes Soares, Viacheslav G. Artyushenko, Alexey Bocharnikov, Iskander Usenov, Tom C. Bakker-Schut, Robert J. Baatenburg de Jong, Eppo Wolvius, Ivo ten Hove, Hetty Mast M.D., Jose A. U. Hardillo, Aniel Sewnaik, Cees Meeuwis M.D., Florence van Lanschot, Dominiek Monserez, Stijn Keereweer, Martin van der Wolf, Elena Sokolova, Senada Koljenovic

Author Affiliations +

Proceedings Volume 11236, Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry; 1123607 (2020) https://doi.org/10.1117/12.2544394
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

In oral cavity cancer only 15% of operations succeed in removing the whole tumor with the required margin of more than 5 mm of surrounding healthy tissue. This negatively affects prognosis. Clearly the hands and eyes of the surgeon do not suffice. We use a fiber optic needle probe for high-wavenumber Raman spectroscopic analysis of the freshly resected tissue to determine if the distance between the resection surface and the tumor is sufficient. A system is under development to inspect the resected tissue in under 15 minutes, while the patient is still in the OR.

Conference Presentation

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Gerwin J. Puppels, Elisa M. L. Barroso, Yassine Aaboubout, Maria Rosa Nunes Soares, Viacheslav G. Artyushenko, Alexey Bocharnikov, Iskander Usenov, Tom C. Bakker-Schut, Robert J. Baatenburg de Jong, Eppo Wolvius, Ivo ten Hove, Hetty Mast M.D., Jose A. U. Hardillo, Aniel Sewnaik, Cees Meeuwis M.D., Florence van Lanschot, Dominiek Monserez, Stijn Keereweer, Martin van der Wolf, Elena Sokolova, and Senada Koljenovic "Intra-operative assessment of tumor resection margins by Raman spectroscopy to guide oral cancer surgery (Conference Presentation)", Proc. SPIE 11236, Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry, 1123607 (9 March 2020); https://doi.org/10.1117/12.2544394

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