We investigated the effects of acute hypoxia on heart rate variability (HRV) parameters during supine rest and moderate-intensity exercise. 27 male (age= 28±11 yr, height= 177±6 cm, mass= 79±9 kg) and 4 female (age= 25±7 yr, height= 169±7 cm, mass= 60±5kg) participants were recruited. Participants rested for 30 minutes in a supine position, after which 5 minutes of isometric squat-stands (0.05 Hz) were performed. This was performed under both normoxic and hypoxic (14.8% oxygen; ~2750m) conditions. Within subject comparisons were made between the last 5 minutes of each supine portion, and between the squat-stand maneuvers at normoxia vs. hypoxia. Depending on normality distribution, a Wilcoxon signed-rank test or a paired sample t-test was used with alpha set at p<0.05. Significant differences in %LF (48±18 vs 56±16), %HF (44±19 vs 35±18), LF/HF ratio (1.8±2 vs 2.3±1), NN50 beats (104±61 vs 82±70), pNN50 (36±22 vs 27±24), SD1 (50±31 vs 42±30), SD2 (101±55 vs 90±46), SD2/SD1 ratio (2.4±1 vs 2.7±1), and % determinism (97±2 vs 98±1) were seen between normoxia and hypoxia, respectively. Significant differences in NN50 (92±26 vs 81±30), pNN50 (21±6 vs 17±7), SD2 (188±60 vs 177±56) and sample entropy (0.3±0.2 vs 0.2±0.1) were also seen during squat-stands between normoxia and hypoxia, respectively. These results suggest changes in physiology and HRV parameters during exposure to acute hypoxia. This research has implications for autonomic function and its influence on cardiac control at altitude.
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