PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
Desmoplastic stiffening of breast carcinoma is the bulk scale manifestation of the extra-cellular matrix (ECM) micromechanical remodeling during neoplastic transformation. We have developed a novel optical imaging technology, termed laser speckle micro-rheology (LSM) for evaluating the micro-mechanical properties of tissue and investigating the implications of the mechano-pathological phenomena to the disease progression. Here, we present a new enhancement to the LSM processing scheme to extract the optical properties from speckle patterns and correct for residual speckle modulations to quantify the shear viscoelastic modulus of breast tissues. By accounting for optical variations, we observed an increased significance in the shear moduli differences between benign lesions and tumors and also between tumors of different histological diagnosis.
Zeinab Hajjarian Kashany,Elena Brachtel,Diane Tshikudi, andSeemantini Nadkarni
"Compensating for variations of optical properties in laser speckle micro-rheology of breast lesions (Conference Presentation)", Proc. SPIE 11239, Dynamics and Fluctuations in Biomedical Photonics XVII, 112390I (9 March 2020); https://doi.org/10.1117/12.2547207
ACCESS THE FULL ARTICLE
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
The alert did not successfully save. Please try again later.
Zeinab Hajjarian Kashany, Elena Brachtel, Diane Tshikudi, Seemantini Nadkarni, "Compensating for variations of optical properties in laser speckle micro-rheology of breast lesions (Conference Presentation)," Proc. SPIE 11239, Dynamics and Fluctuations in Biomedical Photonics XVII, 112390I (9 March 2020); https://doi.org/10.1117/12.2547207