Temperature dependent terahertz spectroscopy of azithromycin dihydrate

Meijiao Huang; Jian Zuo; Cunlin Zhang

doi:10.1117/12.2542283

12 March 2020 Temperature dependent terahertz spectroscopy of azithromycin dihydrate

Meijiao Huang, Jian Zuo, Cunlin Zhang

Proceedings Volume 11441, 2019 International Conference on Optical Instruments and Technology: IRMMW-THz Technologies and Applications; 1144108 (2020) https://doi.org/10.1117/12.2542283
Event: 2019 International Conference on Optical Instruments and Technology, 2019, Beijing, China

Abstract

Terahertz time-domain spectroscopy (THz-TDS) is a sensitive technique to characterize vibrational modes. It is widely used to monitor polymorphism of solids. This study investigated the terahertz (THz) absorption spectra of azithromycin dihydrate over a temperature range from 90 to 300 k to access more information about the structure and vibrational dynamics of hydrates. As the temperature was increased, the absorption peaks became wider and shifted towards lower frequencies. The temperature dependence of the absorption spectra was explained by the anharmonicity of the vibrational potentials. This method provides more information to characterize the temperature dependence of hydrate structures and contributes to the quality monitoring for the pharmaceutical industry.

Citation Download Citation

Meijiao Huang, Jian Zuo, and Cunlin Zhang "Temperature dependent terahertz spectroscopy of azithromycin dihydrate", Proc. SPIE 11441, 2019 International Conference on Optical Instruments and Technology: IRMMW-THz Technologies and Applications, 1144108 (12 March 2020); https://doi.org/10.1117/12.2542283

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