Functional and morphological changes in the testicular tissue of rat newborns during chronic hypoxia: experimental study

T. V. Palatova; G. N. Maslyakova; A. B. Bucharskaya; E. A. Genina; A. N. Bashkatov

doi:10.1117/12.2563415

9 April 2020 Functional and morphological changes in the testicular tissue of rat newborns during chronic hypoxia: experimental study

T. V. Palatova, G. N. Maslyakova, A. B. Bucharskaya, E. A. Genina, A. N. Bashkatov

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Proceedings Volume 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine; 114570N (2020) https://doi.org/10.1117/12.2563415
Event: Saratov Fall Meeting 2019: VII International Symposium on Optics and Biophotonics, 2019, Saratov, Russian Federation

Abstract

The aim of the study is investigation of morphological features of the testicles of rat newborns with different models of intrauterine hypoxia. Fifteen white outbred female rats aged from 4 to 10 months with a weight of 200 ± 30 g were used. Laboratory animals were divided into 3 experimental groups, 5 rats in each. The first group was subjected to a hypoxic hypoxia during pregnancy (21 days). The hypoxia was simulated in accordance with the method of N.N. Karkishchenko (2010). The second group was subjected to a hemic hypoxia during the second and third weeks of pregnancy, in accordance with the methodology of L.M. Sosedova (2012). The third (control) group was not exposed to any treatment during the pregnancy. After delivery, the newborn rat pups were subjected to the measurements of oxygenation degree using the methods of reflectance spectroscopy, then the animals were withdrawn from the experiment; and a morphological study of the testicle tissues was performed. Histological examination of the tissues of the testicles of newborn rats showed signs of impaired blood circulation, dystrophic and necrobiotic changes in the parenchyma.

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T. V. Palatova, G. N. Maslyakova, A. B. Bucharskaya, E. A. Genina, and A. N. Bashkatov "Functional and morphological changes in the testicular tissue of rat newborns during chronic hypoxia: experimental study", Proc. SPIE 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine, 114570N (9 April 2020); https://doi.org/10.1117/12.2563415

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KEYWORDS

Hypoxia

Tissues

Testis

Oxygen

Reflectivity

Animal model studies

Biomedical optics

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