Nanoscopic imaging of molecular conformations in physiological conditions

Yang Zhao; Yun-Sheng Chen

doi:10.1117/12.2568640

20 August 2020 Nanoscopic imaging of molecular conformations in physiological conditions

Yang Zhao, Yun-Sheng Chen

Proceedings Volume 11462, Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XVIII; 1146211 (2020) https://doi.org/10.1117/12.2568640
Event: SPIE Nanoscience + Engineering, 2020, Online Only

Abstract

In this talk, I will discuss how light can be sculpted with engineered nanostructures to enhance chiral light-matter interactions. With these nanostructures, we have developed optical force nanoscopes to visualize and quantify molecular chirality with high sensitivity and resolution. Specifically, we have designed and developed a cavity-enhanced atomic force microscope to image chiral optical forces with nanometer spatial resolution and piconewton force sensitivity. We use this technique to measure the chirality of DNA molecules, on the order of few tens of molecules. These studies provide a foundation for new sensing and imaging techniques at the single molecular to cellular level in-situ and in real time.

Conference Presentation

Citation Download Citation

Yang Zhao and Yun-Sheng Chen "Nanoscopic imaging of molecular conformations in physiological conditions", Proc. SPIE 11462, Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XVIII, 1146211 (20 August 2020); https://doi.org/10.1117/12.2568640

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