Development of a clinical intravascular dual-modality optical coherence tomography and near-infrared autofluorescence/fluorescence imaging platform

Osman O. Ahsen; Zhonglie Piao; Aditya Kumar; Ara B. Bablouzian; Jia Liu; Mason Schellenberg; Paola A. Leon Alarcon; Andreas Wartak; Matthew Beatty; Benjamin Child; Adam Mauskapf; Mazen Albaghdadi; Ryutaro Ikegami; Sarah Giddings; Joseph A. Gardecki; Victoria A. Mathieu; Farouc A. Jaffer M.D.; Guillermo J. Tearney

doi:10.1117/12.2577841

5 March 2021 Development of a clinical intravascular dual-modality optical coherence tomography and near-infrared autofluorescence/fluorescence imaging platform

Osman O. Ahsen, Zhonglie Piao, Aditya Kumar, Ara B. Bablouzian, Jia Liu, Mason Schellenberg, Paola A. Leon Alarcon, Andreas Wartak, Matthew Beatty, Benjamin Child, Adam Mauskapf, Mazen Albaghdadi, Ryutaro Ikegami, Sarah Giddings, Joseph A. Gardecki, Victoria A. Mathieu, Farouc A. Jaffer M.D., Guillermo J. Tearney

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Proceedings Volume 11621, Diagnostic and Therapeutic Applications of Light in Cardiology 2021; 116210O (2021) https://doi.org/10.1117/12.2577841
Event: SPIE BiOS, 2021, Online Only

Abstract

We present our next generation clinical dual-modality OCT and near infrared autofluorescence/fluorescence (NIRAF/NIRF) imaging platform. This platform allows combined tissue microstructure visualization (OCT) and obtaining molecular information either by intrinsic tissue near infrared autofluorescence (NIRAF) or by exogenous near infrared fluorescence contrast agents (NIRF). Components of this platform, OCT-NIRAF/NIRF imaging system, rotary junction and catheters, were developed using an industry standard design control processes to enable quality clinical translation. We have identified sources of image degradation in dual-modality catheter-based imaging (e.g. core-cladding crosstalk in OCT, background noise in fluorescence) and present methods to mitigate their effects. We also show catheter fabrication and validation, as well as automated fluorescence sensitivity and distance calibration methods that ensure robust and repeatable system performance.

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Osman O. Ahsen, Zhonglie Piao, Aditya Kumar, Ara B. Bablouzian, Jia Liu, Mason Schellenberg, Paola A. Leon Alarcon, Andreas Wartak, Matthew Beatty, Benjamin Child, Adam Mauskapf, Mazen Albaghdadi, Ryutaro Ikegami, Sarah Giddings, Joseph A. Gardecki, Victoria A. Mathieu, Farouc A. Jaffer M.D., and Guillermo J. Tearney "Development of a clinical intravascular dual-modality optical coherence tomography and near-infrared autofluorescence/fluorescence imaging platform", Proc. SPIE 11621, Diagnostic and Therapeutic Applications of Light in Cardiology 2021, 116210O (5 March 2021); https://doi.org/10.1117/12.2577841

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KEYWORDS

Optical coherence tomography

Imaging systems

Luminescence

Near infrared

Process control

Tissues

Control systems

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