Assessing cataract formation ex vivo with phase decorrelation OCT

Brecken J. Blackburn; Matthew McPheeters; Michael W. Jenkins; William J. Dupps; Andrew M. Rollins

doi:10.1117/12.2578479

5 March 2021 Assessing cataract formation ex vivo with phase decorrelation OCT

Brecken J. Blackburn, Matthew McPheeters, Michael W. Jenkins, William J. Dupps, Andrew M. Rollins

Proceedings Volume 11623, Ophthalmic Technologies XXXI; 116231S (2021) https://doi.org/10.1117/12.2578479
Event: SPIE BiOS, 2021, Online Only

Conference Poster

Abstract

Changes in the protein aggregation within the ocular lens may be responsible for both presbyopia and cataracts. Treatments for these conditions are under development, but are likely to be most effective when administered early in the disease. Therefore, a technique compatible with in vivo use which could detect early changes in aggregations is desired. Here, we assess if phase-decorrelation OCT may be sensitive to cold-induced protein aggregation in ex vivo porcine lenses. A major challenge of this approach is the relatively weak scattering signal obtained from the lens nucleus while the lens is in situ. We observed a substantial increase in decorrelation time as the cold cataract reversed. Backscatter intensity also decreased as the cold cataract reversed, as expected. However, compared to backscatter intensity, decorrelation is better correlated with cataract reversal.

Citation Download Citation

Brecken J. Blackburn, Matthew McPheeters, Michael W. Jenkins, William J. Dupps, and Andrew M. Rollins "Assessing cataract formation ex vivo with phase decorrelation OCT", Proc. SPIE 11623, Ophthalmic Technologies XXXI, 116231S (5 March 2021); https://doi.org/10.1117/12.2578479

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available