Comparison of methods to assess cerebrovascular reactivity using diffuse correlation spectroscopy

Kyle R. Cowdrick; Erin Buckley

doi:10.1117/12.2577461

5 March 2021 Comparison of methods to assess cerebrovascular reactivity using diffuse correlation spectroscopy

Kyle R. Cowdrick, Erin Buckley

Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 116291A (2021) https://doi.org/10.1117/12.2577461
Event: SPIE BiOS, 2021, Online Only

Abstract

Cerebrovascular reactivity (CVR) refers to the ability of cerebral vasculature to dilate or constrict during vasoactive stimuli. CVR has been shown to be a biomarker for vascular health in a range of disease states. Herein, we use Diffuse Correlation Spectroscopy to quantify cerebrovascular reactivity in 10 healthy adults using 3 different experimental paradigms for CVR assessment: hypercapnia, breath holding, and resting-state. We compare CVR estimations across these 3 paradigms, and we find poor agreement between the methods, underscoring the need for improved understanding of the different mechanisms of action of each intervention on the vasculature.

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Kyle R. Cowdrick and Erin Buckley "Comparison of methods to assess cerebrovascular reactivity using diffuse correlation spectroscopy", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 116291A (5 March 2021); https://doi.org/10.1117/12.2577461

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KEYWORDS

Spectroscopy

Carbon dioxide

Magnetic resonance imaging

Cerebral blood flow

Gold

Hemodynamics

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