Monitoring neural activities in behaving mice utilizing optical fiber-based methods

Ling Fu; Lu He; Xiang Li; Zhongyang Qi

doi:10.1117/12.2578426

5 March 2021 Monitoring neural activities in behaving mice utilizing optical fiber-based methods

Ling Fu, Lu He, Xiang Li, Zhongyang Qi

Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 116291N (2021) https://doi.org/10.1117/12.2578426
Event: SPIE BiOS, 2021, Online Only

Abstract

In recent years, advanced optical methods combined with genetically encoded indicators has gradually become a helpful solution for monitoring neural activities in behaving animals. Among various optical methods, fiber-based ones have become increasingly versatile as they have declined in size but gained in functionality. We developed a nonlinear optical fiber-based endoscope with single-cell resolution, which enables investigating neural activities within single nucleus in freely behaving mice. To further understand how neural activities are coordinated in the complex circuits over different brain regions, we implemented two multichannel fiber photometry systems for multi-site population neural activity recording in head-restrained mice.

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Ling Fu, Lu He, Xiang Li, and Zhongyang Qi "Monitoring neural activities in behaving mice utilizing optical fiber-based methods", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 116291N (5 March 2021); https://doi.org/10.1117/12.2578426

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KEYWORDS

Optical fibers

Brain

Calcium

Photometry

Multimode fibers

Mirrors

Neurons

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