Image-assisted analysis of pathologist slide review as a means of informing optimal digital slide acquisition strategies

Kimberly L. Ashman; Brian Summa; Sharon E. Fox; Jonathon Q. Brown

doi:10.1117/12.2577423

5 March 2021 Image-assisted analysis of pathologist slide review as a means of informing optimal digital slide acquisition strategies

Kimberly L. Ashman, Brian Summa, Sharon E. Fox, Jonathon Q. Brown

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Proceedings Volume 11631, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIX; 116310L (2021) https://doi.org/10.1117/12.2577423
Event: SPIE BiOS, 2021, Online Only

Abstract

In digital pathology, the practice of scanning slides at a single resolution results in more data than is clinically useful. In contrast, using a light microscope, the pathologist adapts magnification according to specimen content. We developed a method of digitizing the analog microscope workflows of pathologists using a microscope camera and video mosaicking with the Scale Invariant Feature Transform (SIFT). Matching this digital record to the whole slide image generates a slide interaction map over time and magnification tiers. The results of the pilot studies suggest data size can be significantly reduced without diminishing the information content required for diagnosis.

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Kimberly L. Ashman, Brian Summa, Sharon E. Fox, and Jonathon Q. Brown "Image-assisted analysis of pathologist slide review as a means of informing optimal digital slide acquisition strategies", Proc. SPIE 11631, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIX, 116310L (5 March 2021); https://doi.org/10.1117/12.2577423

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KEYWORDS

Image analysis

Microscopes

Video

Analog electronics

Cameras

Kidney

Pathology

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