CARS endomicroscopic imaging probe enabled by a double-core double-clad fiber and related focus-combining micro-optical concept

Bernhard Messerschmidt; Ekaterina Pshenay-Severin; Gregor Matz; Karl Reichwald; Jörg Bierlich; Jens Kobelke; Hyeonsoo Bae; Tobias Meyer-Zedler; Michael Schmitt; Jürgen Popp

doi:10.1117/12.2578538

5 March 2021 CARS endomicroscopic imaging probe enabled by a double-core double-clad fiber and related focus-combining micro-optical concept

Bernhard Messerschmidt, Ekaterina Pshenay-Severin, Gregor Matz, Karl Reichwald, Jörg Bierlich, Jens Kobelke, Hyeonsoo Bae, Tobias Meyer-Zedler, Michael Schmitt, Jürgen Popp

Author Affiliations +

Proceedings Volume 11636, Optical Biopsy XIX: Toward Real-Time Spectroscopic Imaging and Diagnosis; 116360A (2021) https://doi.org/10.1117/12.2578538
Event: SPIE BiOS, 2021, Online Only

Abstract

Non-linear endoscopic imaging probes allow for in-vivo, label free tissue histology and thus bring tumour treatment to a new level providing accurate, real time diagnostics. Here we present an endomicroscopic imaging probe for coherent anti-Stokes Raman scattering (CARS) imaging based on a fiber piezo scanner at the distal side of the probe. One of the main hurdles in the implementation of CARS imaging in all-fiber solutions is the generation of a background four-wave-mixing (FWM) signal within the delivery fiber by the Stokes- and pump lasers involved in the process of generation of the nonlinear image. We developed and realised a novel solution based on a silica double-core double-clad (DCDC) fiber, which allows a separate guiding of the exciting Stokes- and pump laser radiation in two separate cores of the delivery fiber. The optical design of the endoscopic probe allows perfect overlap and focusing of the Stokes and pump lasers across the full field of view of the probe.

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Bernhard Messerschmidt, Ekaterina Pshenay-Severin, Gregor Matz, Karl Reichwald, Jörg Bierlich, Jens Kobelke, Hyeonsoo Bae, Tobias Meyer-Zedler, Michael Schmitt, and Jürgen Popp "CARS endomicroscopic imaging probe enabled by a double-core double-clad fiber and related focus-combining micro-optical concept", Proc. SPIE 11636, Optical Biopsy XIX: Toward Real-Time Spectroscopic Imaging and Diagnosis, 116360A (5 March 2021); https://doi.org/10.1117/12.2578538

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