Handheld multi-parametric photoacoustic microscopy

Fenghe Zhong; Zhiqiang Xu; Ruimin Chen; Qifa Zhou; Song Hu

doi:10.1117/12.2577779

5 March 2021 Handheld multi-parametric photoacoustic microscopy

Fenghe Zhong, Zhiqiang Xu, Ruimin Chen, Qifa Zhou, Song Hu

Proceedings Volume 11642, Photons Plus Ultrasound: Imaging and Sensing 2021; 1164212 (2021) https://doi.org/10.1117/12.2577779
Event: SPIE BiOS, 2021, Online Only

Abstract

We report a handheld multi-parametric photoacoustic microscopy system for functional and oxygen-metabolic imaging of the human skin microvasculature. With the high spatiotemporal resolution (3 μm and 10-Hz frame rate), the traverse of single red blood cells through the capillary can be visualized, from which the flow speed can be quantified. Furthermore, the multi-parametric measurement enables comprehensive quantification of the oxygen saturation and release in individual microvessels. The utility of this new technique has been demonstrated by studying the microvascular reactivity in humans.

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Fenghe Zhong, Zhiqiang Xu, Ruimin Chen, Qifa Zhou, and Song Hu "Handheld multi-parametric photoacoustic microscopy", Proc. SPIE 11642, Photons Plus Ultrasound: Imaging and Sensing 2021, 1164212 (5 March 2021); https://doi.org/10.1117/12.2577779

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KEYWORDS

Photoacoustic microscopy

Blood

Imaging systems

Blood pressure

Capillaries

In vivo imaging

Oxygen

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