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5 March 2021 Nearly-incompressible transverse isotropy in the cornea: comparing mechanical tests with acoustic micro-tapping based optical coherence elastography
Mitchell A. Kirby, Hong-Cin Liou, John J. Pitre, David S. Li, Tueng T. Shen M.D., Ruikang Wang, Matthew O'Donnell, Ivan Pelivanov
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Proceedings Volume 11645, Optical Elastography and Tissue Biomechanics VIII; 1164515 (2021) https://doi.org/10.1117/12.2577045
Event: SPIE BiOS, 2021, Online Only
Abstract
Accurate estimates of corneal mechanical properties may improve diagnosis and treatment of many ophthalmic conditions. Recently, we introduced a nearly incompressible transversely isotropic (NITI) model based on two independent shear moduli determining tensile and out-of-plane shear behavior. Here, we directly compare acoustic micro-tapping OCE (AμT-OCE) modulus estimates with those obtained from mechanical testing on ex-vivo porcine corneas. Both OCE and mechanical testing show tensile behavior governed by a Young’s modulus on the order of MPa and out-of-plane shear behavior by a modulus on the order of tens of kPa, suggesting strong anisotropy in the cornea.
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Mitchell A. Kirby, Hong-Cin Liou, John J. Pitre, David S. Li, Tueng T. Shen M.D., Ruikang Wang, Matthew O'Donnell, and Ivan Pelivanov "Nearly-incompressible transverse isotropy in the cornea: comparing mechanical tests with acoustic micro-tapping based optical coherence elastography", Proc. SPIE 11645, Optical Elastography and Tissue Biomechanics VIII, 1164515 (5 March 2021); https://doi.org/10.1117/12.2577045
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KEYWORDS
Cornea
Acoustics
Coherence (optics)
Elastography
Analytical research
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