Localized pulsed photohyperthtermia: Laser-ablated silicon nanoparticles as photosensitizers

Alexander Kharin; Victor Timoshenko; Andrey V. Kabashin; Vladislav Oleschenko; Anton Popov

doi:10.1117/12.2586468

5 March 2021 Localized pulsed photohyperthtermia: Laser-ablated silicon nanoparticles as photosensitizers

Alexander Kharin, Victor Timoshenko, Andrey V. Kabashin, Vladislav Oleschenko, Anton Popov

Proceedings Volume 11675, Synthesis and Photonics of Nanoscale Materials XVIII; 116750J (2021) https://doi.org/10.1117/12.2586468
Event: SPIE LASE, 2021, Online Only

Abstract

Silicon (Si) nanoparticles (NPs) synthesized by pulsed laser ablation in water are explored as sensitizers of photothermal therapy under a laser excitation in the window of relative tissue transparency. Based on theoretical calculations and experimental data, it is shown that the NPs can be heated up to temperatures above 42–50 °C by laser diode irradiation at 808 nm in continuous wave (CW) and quasi-continuous wave (QCW) regimes. Profiting from the laser-induced heating, a high efficiency Si-NPs as sensitizers of the hyperthermia of cells in Paramecium Caudatum model is demonstrated. The QCW regime is found to be more efficient, leading to complete cell destruction even under relatively mild laser irradiation conditions. The obtained data evidence a great potential in using laser-ablated Si-NPs as sensitizers of photohyperthermia in antibacterial or cancer therapy applications

Conference Presentation

Citation Download Citation

Alexander Kharin, Victor Timoshenko, Andrey V. Kabashin, Vladislav Oleschenko, and Anton Popov "Localized pulsed photohyperthtermia: Laser-ablated silicon nanoparticles as photosensitizers", Proc. SPIE 11675, Synthesis and Photonics of Nanoscale Materials XVIII, 116750J (5 March 2021); https://doi.org/10.1117/12.2586468

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