Programmable vascular targeted photodynamic therapy device for animal experiment

Wenrui Kang; Xu Wang; Bingshuai Liu; Fanchao Cheng; Xiaoming Hu

doi:10.1117/12.2587352

2 December 2020 Programmable vascular targeted photodynamic therapy device for animal experiment

Wenrui Kang, Xu Wang, Bingshuai Liu, Fanchao Cheng, Xiaoming Hu

Author Affiliations +

Proceedings Volume 11717, 24th National Laser Conference & Fifteenth National Conference on Laser Technology and Optoelectronics; 117172Q (2020) https://doi.org/10.1117/12.2587352
Event: 24th National Laser Conference & Fifteenth National Conference on Laser Technology and Optoelectronics, 2020, Shanghai, China

Abstract

Vascular targeted photodynamic therapy (VPDT) is a new targeted therapy that relies on light as a precise spatially and temporally stimulus. An improved understanding of the interaction between photosensitizers, oxygen and light elements is of great significance to improve the outcomes. A VPDT device for animal evaluation is designed to meet the needs on the regulation of light distribution and irradiance on a same sample. The device is composed of a programmable light source and a micro-camera. The irradiance and spatial distribution can be adjusted by the light-emitting diode current and the duty cycle of the digital micromirror. Experiments show that the optical uniformity of the device is better than 96 percent, the dynamic range is up 28,815 to 1, and the position resolution is 7.6 micron, which can be used for animal experiment.

Citation Download Citation

Wenrui Kang, Xu Wang, Bingshuai Liu, Fanchao Cheng, and Xiaoming Hu "Programmable vascular targeted photodynamic therapy device for animal experiment", Proc. SPIE 11717, 24th National Laser Conference & Fifteenth National Conference on Laser Technology and Optoelectronics, 117172Q (2 December 2020); https://doi.org/10.1117/12.2587352

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