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Recent advances in materials and fabrication concepts for the creation of soft electronics coupled with miniaturization of wireless energy harvesting schemes enable the construction of high-performance electronic and optoelectronic systems with sizes, shapes and physical properties matched to biological systems. Applications range from continuous monitors for health diagnosis to minimally invasive exploratory tools for neuroscience. This talk introduces science and engineering aspects for the creation of soft devices with wireless power transfer and data communication capabilities and discusses application in minimally invasive exploratory neuromodulation tools and imperceptible body-worn sensing devices. Specifically, we present two new classes of devices for implantable and wearable biointegrated electronic devices. Firstly, we will introduce wireless, battery free and fully implantable neuromodulation tools that provide unparalleled capabilities to modulate the central nervous system. The tools enable new experimental paradigms in a range of complex environments and contexts that cannot be explored with conventional technologies. The devices feature miniaturized form factor and technologies that are rapidly scalable to enable broad dissemination while still maintaining compatibility with noninvasive imaging technologies such as computed tomography (CT) and magnetic resonance imaging (MRI). Specifically, we will highlight 1. Current advances in highly miniaturized wireless and battery free photometric recording devices that enable the study of neural dynamics in ethnologically relevant environments in young animal models unlocking new experimental paradigms to uncover the working principles of the developing brain. 2. Wireless battery-free and subdermally implantable optogenetic stimulation tools that enable: neural activation in freely flying birds; transcranial optogenetic stimulation in mice without cranial surgery; long range neural activation in ethologically relevant environments. Secondly, we will present a new class of wearable wireless, battery free, long range, personalized and multimodal sensors system. The first of its kind device architecture is shaped by physiology and enables uninterrupted 24 hour data streams with high fidelity over long periods of time. The devices feature highly personalized device geometries that solve prevalent problems of current adhesive based wearable devices while still retaining intimate contact.
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