Stain transfer for automatic annotation of malignant lymphoma regions in H&E stained whole slide histopathology images

Ryoichi Koga; Noriaki Hashimoto; Tatsuya Yokota; Masato Nakaguro; Kei Kohno; Shigeo Nakamura; Ichiro Takeuchi; Hidekata Hontani

doi:10.1117/12.2590720

20 April 2021 Stain transfer for automatic annotation of malignant lymphoma regions in H&E stained whole slide histopathology images

Ryoichi Koga, Noriaki Hashimoto, Tatsuya Yokota, Masato Nakaguro, Kei Kohno, Shigeo Nakamura, Ichiro Takeuchi, Hidekata Hontani

Author Affiliations +

Proceedings Volume 11792, International Forum on Medical Imaging in Asia 2021; 117920R (2021) https://doi.org/10.1117/12.2590720
Event: International Forum on Medical Imaging in Asia 2021, 2021, Taipei, Taiwan

Abstract

We propose a method to transfer a given pathology image stained by some immunostaining to a H&E stained one. When one construct a classifier that estimates the subtype of malignant lymphoma from a given H&E stained pathology image, one needs a set of training H&E stained whole slide images in which the tumor regions are annotated. The annotation is not easy and requires large human resources. Here, it is known that some immunostaining stains only some specific tumor cells and the tumor region detection from the immunostained images is straightforward. It means once you transfer the immunostained images to H&E stained ones, you can easily obtain a set of virtually H&E stained images with annotation of tumor regions. In this manuscript, we report on the proposed method and experimental results of stain transfer from CD20 stained images to H&E stained ones.

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Ryoichi Koga, Noriaki Hashimoto, Tatsuya Yokota, Masato Nakaguro, Kei Kohno, Shigeo Nakamura, Ichiro Takeuchi, and Hidekata Hontani "Stain transfer for automatic annotation of malignant lymphoma regions in H&E stained whole slide histopathology images", Proc. SPIE 11792, International Forum on Medical Imaging in Asia 2021, 117920R (20 April 2021); https://doi.org/10.1117/12.2590720

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