Opto-Thermo-Electrohydrodynamic Tweezers: Towards On-chip Single-Molecule Trapping and Analysis

Justus C. Ndukaife; Chuchuan Hong; Sen Yang

doi:10.1117/12.2595509

1 August 2021 Opto-Thermo-Electrohydrodynamic Tweezers: Towards On-chip Single-Molecule Trapping and Analysis

Justus C. Ndukaife, Chuchuan Hong, Sen Yang

Proceedings Volume 11798, Optical Trapping and Optical Micromanipulation XVIII; 1179823 (2021) https://doi.org/10.1117/12.2595509
Event: SPIE Nanoscience + Engineering, 2021, San Diego, California, United States

Abstract

The trapping and dynamic manipulation of nanoscale biological molecules such as proteins and exosomes using the conventional optical tweezer technology have been met with challenges. This arises because of the substantial optical intensity required, which poses photo-induced damage to the biomolecules. In this talk, I will introduce a new kind of optically controlled nanotweezers termed Opto-Thermo-Electrohydrodynamic Tweezers (OTET) that enables the stable trapping and dynamic manipulation of sub-10 nm biomolecules at locations that are several microns away from the high-intensity laser focus, where they experience both negligible photothermal heating and light intensity. This novel non-invasive optical nanotweezer is expected to open new horizons in life science and medicine by offering an unprecedented level of control of tiny nano-sized biological objects in solution without photo-induced damage.

Conference Presentation

Citation Download Citation

Justus C. Ndukaife, Chuchuan Hong, and Sen Yang "Opto-Thermo-Electrohydrodynamic Tweezers: Towards On-chip Single-Molecule Trapping and Analysis", Proc. SPIE 11798, Optical Trapping and Optical Micromanipulation XVIII, 1179823 (1 August 2021); https://doi.org/10.1117/12.2595509

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Biological research

Optical tweezers

Biomedical optics

Life sciences

Medicine

Particles

Physics

Show All Keywords

Keywords/Phrases

Search In:

Publication Years