Optical vortex microrheology of turbid viscoelastic tissue

Jiaxing Gong; Qi Li; Hui Zhang; Jing Wang

doi:10.1117/12.2602200

9 October 2021 Optical vortex microrheology of turbid viscoelastic tissue

Jiaxing Gong, Qi Li, Hui Zhang, Jing Wang

Proceedings Volume 11900, Optics in Health Care and Biomedical Optics XI; 119000H (2021) https://doi.org/10.1117/12.2602200
Event: SPIE/COS Photonics Asia, 2021, Nantong, JS, China

Abstract

We proposed a new approach to evaluate tissue rheological properties by assessing the stochastic motion of optical vortices in the pseudo-phase representation of laser speckles. By studying the vortex MSD and VAF, we observed the anomalous diffusion of optical vortices and evaluated the viscoelastic modulus of different gel phantoms and tissue samples with diverse mechanical and optical properties. We established the direct relationship which connects the microscopic motion of the optical vortices to the macroscopic viscoelastic response of the multiple scattering viscoelastic media. We can imagine amounts of biomedical applications including blood coagulability monitoring, atherosclerotic plaque characterization, and tumor localization.

Conference Presentation

Citation Download Citation

Jiaxing Gong, Qi Li, Hui Zhang, and Jing Wang "Optical vortex microrheology of turbid viscoelastic tissue", Proc. SPIE 11900, Optics in Health Care and Biomedical Optics XI, 119000H (9 October 2021); https://doi.org/10.1117/12.2602200

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