Optimal temperature control in laser hyperthermia

Douglas Robert Wyman; Carrie-Lynne Swift; Rosemarie A. Siwek; Brian C. Wilson

doi:10.1117/12.17601

1 July 1990 Optimal temperature control in laser hyperthermia

Douglas Robert Wyman, Carrie-Lynne Swift, Rosemarie A. Siwek, Brian C. Wilson

Proceedings Volume 1201, Optical Fibers in Medicine V; (1990) https://doi.org/10.1117/12.17601
Event: OE/LASE '90, 1990, Los Angeles, CA, United States

Abstract

Interstitial laser hypefthezmia is a tecbnique for the treatment of malignant tumors that involves heating a tumor volume by directing infrared laser light, usually from an Nd: YZG laser, into the volume through interstitially iirlanted optical fibers . We have developed a multi-source, multi-sensor corruter controlled laser hyperthermia system similar to that first described by Daikuzono et al .' In this system, irrlanted inicrothermocouple sensors provide internal terrerature feedback to an algorithm that dynamically deteimines how much light should be directed into the various optical fiber sources, in order to maintain a spatially and tenporally unifoirn teriperature distribution in a tumor volume. This algorithm allows for the tissue thermal response to light to change over time (nonlinear system) , for exarrle, as tissue terterature increases or as tissue damage is incurred. The algorithm eiiploys an original nonlinear system control method that involves a periodic and indirect determination of how each microthermocouple responds to a unit irrulse of light directed down each fiber. Initial testing of the system in a ground beef phantom is described. By accommodating a nonlinear system, our irrlementation of laser hyperthermia should allow for optimal teirerature control.

Citation Download Citation

Douglas Robert Wyman, Carrie-Lynne Swift, Rosemarie A. Siwek, and Brian C. Wilson "Optimal temperature control in laser hyperthermia", Proc. SPIE 1201, Optical Fibers in Medicine V, (1 July 1990); https://doi.org/10.1117/12.17601

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