Pulmonary alveoli cluster analysis of 3D human lung microstructure using synchrotron radiation micro-CT

Kurumi Saito; Keisuke Fukuda; Yoshiki Kawata; Keiji Umetani; Yasutaka Nakano; Hiroaki Sakai; Toshihiro Okamoto; Noboru Niki

doi:10.1117/12.2612692

4 April 2022 Pulmonary alveoli cluster analysis of 3D human lung microstructure using synchrotron radiation micro-CT

Kurumi Saito, Keisuke Fukuda, Yoshiki Kawata, Keiji Umetani, Yasutaka Nakano, Hiroaki Sakai, Toshihiro Okamoto, Noboru Niki

Author Affiliations +

Proceedings Volume 12036, Medical Imaging 2022: Biomedical Applications in Molecular, Structural, and Functional Imaging; 120360G (2022) https://doi.org/10.1117/12.2612692
Event: SPIE Medical Imaging, 2022, San Diego, California, United States

Abstract

3D microstructural analysis of the human lung can provide unknown information about lung growth and progression of lung diseases. In this study, the alveolar walls of alveolar ducts and alveolar sacs of normal adult lungs were analyzed and classified into primary and secondary septa. The procedure is as follows. (1) 11 lung specimens were prepared by the Heitzman's method, (2) 3D micro-CT experiments were executed using BL20B2 at SPring-8, (3) Alveolar walls were extracted from 3D reconstructed images (12,429 × 12,429 × 4,800, pixel size 3 μm), and (4) Primary and secondary septa were classified by principal component analysis of alveolar walls. 3D structure of alveolar ducts and alveolar walls in normal adult lungs were clarified.

Conference Presentation

Citation Download Citation

Kurumi Saito, Keisuke Fukuda, Yoshiki Kawata, Keiji Umetani, Yasutaka Nakano, Hiroaki Sakai, Toshihiro Okamoto, and Noboru Niki "Pulmonary alveoli cluster analysis of 3D human lung microstructure using synchrotron radiation micro-CT", Proc. SPIE 12036, Medical Imaging 2022: Biomedical Applications in Molecular, Structural, and Functional Imaging, 120360G (4 April 2022); https://doi.org/10.1117/12.2612692

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available