Design of brain simulating liquid and numeric phantoms for evaluating hemodynamic changes in intraoperative functional brain mapping studies

Charly Caredda; Laurent Mahieu-Williame; Raphaël Sablong; Michaël Sdika; Jacques Guyotat; Bruno Montcel

doi:10.1117/12.2621235

24 May 2022 Design of brain simulating liquid and numeric phantoms for evaluating hemodynamic changes in intraoperative functional brain mapping studies

Charly Caredda, Laurent Mahieu-Williame, Raphaël Sablong, Michaël Sdika, Jacques Guyotat, Bruno Montcel

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Proceedings Volume 12146, Clinical Biophotonics II; 121460D (2022) https://doi.org/10.1117/12.2621235
Event: SPIE Photonics Europe, 2022, Strasbourg, France

Abstract

The optical imaging described here is a marker-free, contactless, and non-invasive technique that is able to monitor hemodynamic brain response following neuronal activation during neurosurgery. However, a robust quantification is complicated to perform during neurosurgery due the critical context of the operating room, which makes the calibration and adjustment of optical devices more complex. To overcome this issue, tissue-simulating objects that mimic the properties of biological tissues are required for the development of detection or diagnostic imaging systems. In this study, we evaluated the performance of quantification of chromophore concentration changes measured by experimental setups using two phantoms: a liquid and a numeric brain-simulating phantom. These phantoms mimicked an exposed cerebral cortex as well as the slow concentration changes that occur after neuronal stimulation and the periodic changes due to heartbeat.

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Charly Caredda, Laurent Mahieu-Williame, Raphaël Sablong, Michaël Sdika, Jacques Guyotat, and Bruno Montcel "Design of brain simulating liquid and numeric phantoms for evaluating hemodynamic changes in intraoperative functional brain mapping studies", Proc. SPIE 12146, Clinical Biophotonics II, 121460D (24 May 2022); https://doi.org/10.1117/12.2621235

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KEYWORDS

Brain

Chromophores

Hemodynamics

Brain mapping

Scattering

Tissues

Absorption

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