Flicker-noise spectroscopy analysis of magnetoencephalogram signals in diagnosis and treatment of photosensitive epilepsy

Sergey A. Demin; Valentin A. Yunusov; Sergey F. Timashev

doi:10.1117/12.2623095

29 April 2022 Flicker-noise spectroscopy analysis of magnetoencephalogram signals in diagnosis and treatment of photosensitive epilepsy

Sergey A. Demin, Valentin A. Yunusov, Sergey F. Timashev

Author Affiliations +

Proceedings Volume 12194, Computational Biophysics and Nanobiophotonics; 1219402 (2022) https://doi.org/10.1117/12.2623095
Event: XXV Annual Conference Saratov Fall Meeting 2021; and IX Symposium on Optics and Biophotonics, 2021, Saratov, Russian Federation

Abstract

Our study demonstrates the potential of Flicker-Noise Spectroscopy analysis of neuromagnetic brain responses (magnetoencephalograms) in possible diagnosis and estimating the effectiveness of treatment of photosensitive epilepsy. The tendency of the organism to restore the synchronization to its normal levels is considered the cornerstone of the analysis. A two-parameter Flicker-Noise Spectroscopy cross-correlation function is applied to show that the breakdown of frequency-phase synchronization in the magnetoencephalograms of the patient can be associated with two distinct mechanisms: high-frequency resonances (50-100 Hz) at specific brain areas and changes in high-frequency stochastic components for other brain areas. Our analysis also reveals a certain disruption of regular behavior and occurrence of asymmetry in three-dimensional plots of the cross-correlation function for some healthy controls, suggesting that these individuals may be susceptible to photosensitive epilepsy. We believe that a similar cross-correlation analysis based on appropriate biomedical signals may be used to assess the effectiveness of medical treatment for other diseases and conditions.

Citation Download Citation

Sergey A. Demin, Valentin A. Yunusov, and Sergey F. Timashev "Flicker-noise spectroscopy analysis of magnetoencephalogram signals in diagnosis and treatment of photosensitive epilepsy", Proc. SPIE 12194, Computational Biophysics and Nanobiophotonics, 1219402 (29 April 2022); https://doi.org/10.1117/12.2623095

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KEYWORDS

Epilepsy

Magnetoencephalography

Brain

Sensors

Complex systems

Spectroscopy

Visualization

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