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17 March 2023 Noninvasive optical biopsy of human oral lichen planus in vivo by optical coherence tomography
Yuliia Gruda, Jonas Golde, Jiawen Li, Marius Albrecht, Christian Schnabel, Dominik Haim, Guenter Lauer, Korinna Joehrens, Michaela Buckova, Robert A. McLaughlin, Julia Walther
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Proceedings Volume 12354, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2023; 123540A (2023) https://doi.org/10.1117/12.2648925
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Modern noninvasive imaging techniques are used in many areas of medical research, particularly where an additional modality is required to support close monitoring during pre- or post-care. In oral medicine, the combination of an experienced clinician and supporting noninvasive optical devices for oral imaging, such as optical coherence tomography (OCT), may ensure improved diagnosis. In this study, the pathological features of lichenoid oral mucosa were noninvasively imaged with our miniaturized pen-like OCT probe and compared to adjacent healthy areas. The non-homogeneous epithelial (EP) layer, increased cornification of the EP surface and unidentifiable basement membrane are the most important features recorded.
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Yuliia Gruda, Jonas Golde, Jiawen Li, Marius Albrecht, Christian Schnabel, Dominik Haim, Guenter Lauer, Korinna Joehrens, Michaela Buckova, Robert A. McLaughlin, and Julia Walther "Noninvasive optical biopsy of human oral lichen planus in vivo by optical coherence tomography", Proc. SPIE 12354, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2023, 123540A (17 March 2023); https://doi.org/10.1117/12.2648925
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KEYWORDS
Optical coherence tomography
In vivo imaging
Biopsy
Medicine
Tissues
Medical diagnostics
Natural surfaces
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